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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1993-7-29
|
| pubmed:abstractText |
Cancer patients treated with anthracycline derivatives are at risk for perioperative cardiovascular decompensation. The authors studied hemodynamic performance before, during, and after laparotomy in 14 anthracycline-treated patients with ovarian carcinoma. General anesthesia was maintained with 70% N2O in O2, and patients were randomized to receive supplementation with either isoflurane, 0.59% end-tidal +/- 0.04 (mean +/- SE), or fentanyl, 2.67 micrograms/kg +/- 0.49 as a loading dose, and a total dose of 7.16 micrograms/kg +/- 0.71. The degree of hemodynamic stability relative to the baseline was assessed. There was no obvious superiority of either technique prior to the skin incision. However, during and immediately after surgery, a clearer tendency for isoflurane-N2O to result in better hemodynamic stability was found. Isoflurane-N2O demonstrated significantly smaller change scores in systemic vascular resistance (SVR) and cardiac index (CI). At the start of surgery, the isoflurane-N2O change in SVR was 228.08 dyne.sec.cm-5 compared to 479.58 for the fentanyl patients, (P = 0.002); at the end of surgery the corresponding means were -12.09 and 703.14 dyne.sec.cm-5, respectively, (P = 0.002). Isoflurane-N2O was associated with significantly greater CI stability in the early postoperative period: the isoflurane-N2O mean change was -0.081 L/min/m2, versus -0.993 for the fentanyl-N2O patients, (P = 0.005). The authors conclude that anthracycline-treated patients who do not have overt evidence of cardiomyopathy can be safely anesthetized with either anesthetic technique. However, during surgery and in the early postoperative period, an isoflurane-N2O technique appears to offer better hemodynamic stability.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1053-0770
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
307-11
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8518377-Acid-Base Imbalance,
pubmed-meshheading:8518377-Anesthesia, Inhalation,
pubmed-meshheading:8518377-Anesthesia, Intravenous,
pubmed-meshheading:8518377-Antibiotics, Antineoplastic,
pubmed-meshheading:8518377-Atrial Function, Right,
pubmed-meshheading:8518377-Blood Pressure,
pubmed-meshheading:8518377-Cardiac Output,
pubmed-meshheading:8518377-Electrocardiography,
pubmed-meshheading:8518377-Female,
pubmed-meshheading:8518377-Fentanyl,
pubmed-meshheading:8518377-Heart Rate,
pubmed-meshheading:8518377-Hemodynamics,
pubmed-meshheading:8518377-Humans,
pubmed-meshheading:8518377-Isoflurane,
pubmed-meshheading:8518377-Laparotomy,
pubmed-meshheading:8518377-Middle Aged,
pubmed-meshheading:8518377-Ovarian Neoplasms,
pubmed-meshheading:8518377-Pulmonary Artery,
pubmed-meshheading:8518377-Pulmonary Wedge Pressure,
pubmed-meshheading:8518377-Risk Factors,
pubmed-meshheading:8518377-Stroke Volume,
pubmed-meshheading:8518377-Time Factors,
pubmed-meshheading:8518377-Vascular Resistance,
pubmed-meshheading:8518377-Ventricular Function, Left
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Isoflurane versus fentanyl: hemodynamic effects in cancer patients treated with anthracyclines.
|
| pubmed:affiliation |
Department of Anesthesiology and Critical Care Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|