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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1993-7-22
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pubmed:abstractText |
Exposure of primary murine cortical neuron cultures to N-methyl-D-aspartate (NMDA) resulted in neuronal death as evidenced by release of lactate dehydrogenase (LDH) into the media. The addition of N-nitro-L-arginine (N-Arg) protected the neurons from death in a concentration-dependent manner when added after the NMDA, but not when the N-Arg was present with the NMDA. Protection by N-Arg was lost if L-arginine containing media was added to the cultures prior to the addition of the N-Arg. Treatment of the neurons with kainate prior to NMDA reduced subsequent NMDA-induced damage which was not prevented with N-Arg. These results suggest that delayed production of nitric oxide (NO) contributes to NMDA-induced neuronal damage in culture.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
566-8
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:8513140-Animals,
pubmed-meshheading:8513140-Arginine,
pubmed-meshheading:8513140-Cell Death,
pubmed-meshheading:8513140-Cells, Cultured,
pubmed-meshheading:8513140-Cerebral Cortex,
pubmed-meshheading:8513140-L-Lactate Dehydrogenase,
pubmed-meshheading:8513140-Mice,
pubmed-meshheading:8513140-N-Methylaspartate,
pubmed-meshheading:8513140-Neurons,
pubmed-meshheading:8513140-Nitric Oxide,
pubmed-meshheading:8513140-Nitroarginine
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pubmed:year |
1993
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pubmed:articleTitle |
Delayed production of nitric oxide contributes to NMDA-mediated neuronal damage.
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pubmed:affiliation |
Biology Department, Fisons Pharmaceuticals, Rochester, NY 14603.
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pubmed:publicationType |
Journal Article
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