|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005847,
umls-concept:C0030685,
umls-concept:C0033567,
umls-concept:C0205198,
umls-concept:C0391871,
umls-concept:C0677535,
umls-concept:C0680255,
umls-concept:C0950386,
umls-concept:C1283071,
umls-concept:C1948023,
umls-concept:C1963578
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|
pubmed:issue |
8115
|
|
pubmed:dateCreated |
1979-5-23
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|
pubmed:abstractText |
Ingestion of 1.2 g Bay g 6575 daily for 1 week by six healthy volunteers had no effect on blood-coagulation, fibrinolysis, or platelet aggregation in vitro, but it seemed to inhibit platelet aggregation in vivo (shown by a smaller reduction in the platelet aggregate ratio after venous occlusion). Plasma drawn from five volunteers after ingestion of a single dose of 1.2 g of the drug stimulated prostacyclin release from slices of rat aorta which had been washed until they stopped releasing anti-aggregating substances, whereas plasma from the same individuals before ingestion of the substance did not. Administration of either Bay g 6575 or dipyridamole alone had no effect on platelet aggregation in vitro, but combined administration resulted in a striking and prolonged inhibition of A.D.P.-induced platelet aggregation. It is proposed that the previously described antithrombotic properties of Bay g 6575 in animals are due to stimulation of prostacyclin release from the vessel wall, and that this effect is also demonstrable in man.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0140-6736
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
10
|
|
pubmed:volume |
1
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
518-20
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|
pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:85106-Adenosine Diphosphate,
pubmed-meshheading:85106-Administration, Oral,
pubmed-meshheading:85106-Animals,
pubmed-meshheading:85106-Aorta,
pubmed-meshheading:85106-Blood Coagulation,
pubmed-meshheading:85106-Clinical Trials as Topic,
pubmed-meshheading:85106-Culture Media,
pubmed-meshheading:85106-Dipyridamole,
pubmed-meshheading:85106-Double-Blind Method,
pubmed-meshheading:85106-Drug Synergism,
pubmed-meshheading:85106-Epoprostenol,
pubmed-meshheading:85106-Fibrinolysis,
pubmed-meshheading:85106-Fibrinolytic Agents,
pubmed-meshheading:85106-Humans,
pubmed-meshheading:85106-Male,
pubmed-meshheading:85106-Platelet Aggregation,
pubmed-meshheading:85106-Prostaglandins,
pubmed-meshheading:85106-Pyrazoles,
pubmed-meshheading:85106-Rats,
pubmed-meshheading:85106-Stimulation, Chemical
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|
pubmed:year |
1979
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|
pubmed:articleTitle |
Stimulation of prostacyclin release from vessel wall by Bay g 6575, an antithrombotic compound.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
In Vitro,
Controlled Clinical Trial
|
