Linked Life Data

8510011

Source:http://linkedlifedata.com/resource/pubmed/id/8510011

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-7-14
pubmed:abstractText
The mode of action of 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), an inhibitor of the Cl(-)-HCO3- exchanger, on gastric acid secretion has been studied in vitro and in vivo. In the mouse isolated whole stomach preparation, DIDS (100 microM-1 mM) inhibited gastric acid secretion induced by histamine or bethanechol in a concentration-dependent fashion. On the other hand, DIDS, at a concentration enough to reduce the stimulated acid secretion, did not inhibit basal acid secretion in the resting preparation. In the perfused stomach of urethane-anesthetized rats, DIDS (1-10 mg/kg i.v.) inhibited gastric acid secretion stimulated by histamine, bethanechol or tetragastrin, whereas DIDS did not inhibit basal acid secretion. In pylorus-ligated rats, DIDS (3-30 mg/kg) administered intraduodenally also inhibited gastric acid output as well as gastric juice volume when administered immediately after ligation. When injected 6 h before ligation, DIDS inhibited the gastric acid secretion. However, this potency was weak in comparison with that observed when DIDS was administered immediately after ligation. These results demonstrate that DIDS can inhibit stimulated gastric acid secretion in vitro and in vivo, probably through its inhibitory effect on the Cl(-)-HCO3- exchanger.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
265
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1313-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Inhibition of gastric acid secretion in vivo and in vitro by an inhibitor of Cl(-)-HCO3- exchanger, 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid.
pubmed:affiliation
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't