Linked Life Data

850870

Source:http://linkedlifedata.com/resource/pubmed/id/850870

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1977-5-27
pubmed:abstractText
The acute and chronic changes produced in canine femoral arteries by ischemia and by perfusion with D10W were examined by light and by scanning electron microscopy. Mild changes of injury characterized by medial and adventitial inflammation and an increase in intimal lining cells occur following 30 minutes of perfusion with return to a normal microscopic appearance within one week. Perfusion for 6 hours produces significant injury to the entire arterial wall, as evidenced by depletion of cells and elastin from the media, replacement with collagen, and eventual fibrosis. The intimal surface is replaced by a layer of spindle cells which appear to originate in the media. The internal elastic membrane is flattened and thrombosis is prominent, particularly in areas where medial fibrosis is severe. Many of the vascular changes produced by perfusion injury may persist for 3 months and some may even by permanent. A period of 6 hours of ischemia also produces similar but less prominent alterations in vascular morphology which return to near-normal appearance within 8 weeks.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0039-6060
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
527-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Serial changes in arterial endothelium following ischemia and perfusion.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.