Linked Life Data

8505256

Source:http://linkedlifedata.com/resource/pubmed/id/8505256

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-7-8
pubmed:abstractText
The disposition of pituitary-derived bovine growth hormone (pbST) and of a recombinant bovine growth hormone (rbST) produced by Lilly (somidobove, USAN) were compared after an intravenous bolus administration (36.69 micrograms/kg for pbST and 35 micrograms/kg for rbST) to eight lactating cows in a crossover study. It was shown that dose-dependent parameters (volume of distribution, clearance) were significantly different between the two test articles. The steady mean state volume of distribution (.10 +/- .018 vs .12 +/- .015 L/kg) and clearance (.119 +/- .012 vs .143 +/- .011 L.kg-1.h-1) were lower for the pbST than for the somidobove. In contrast, the mean (+/- SD) residence times were not different for the two test articles (50.0 +/- 8.6 vs 46.9 +/- 5.9 min for pbST and somidobove, respectively). The origin of the difference is unclear, but it cannot be explained by the slight difference between the administered dose of the two test articles (< 5%) because the actual dose rate was used to calculate all dose-dependent parameters.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-8812
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1219-25
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Pharmacokinetics of a recombinant bovine growth hormone and pituitary bovine growth hormone in lactating dairy cows.
pubmed:affiliation
INRA, Unité Associée de Physiopathologie et de Toxicologie Experimentales, Ecole Nationale Vétérinaire de Toulouse, France.
pubmed:publicationType
Journal Article, Comparative Study