Linked Life Data

8504215

Source:http://linkedlifedata.com/resource/pubmed/id/8504215

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-7-2
pubmed:abstractText
The MHC class I heavy chain and beta 2-microglobulin are cell surface proteins, and are synthesized on membrane bound ribosomes. They are co-translationally inserted into the endoplasmic reticulum (ER) membrane and assemble with antigenic peptides in the lumen of this compartment. These peptides are believed to be generated in the cytosol, and must be protected from degradation prior to translocation across the ER membrane. Putative peptide transporters (TAP1 and 2) belonging to the ABC transporter family of proteins, have been suggested to function in this process, and have been shown to be essential for MHC class I antigen assembly. The finding that peptides were translocated across the ER membrane in microsomes prepared from cells lacking the TAP genes has challenged this view. In this review we discuss the different events leading to correct assembly of MHC class I antigens. We suggest the TAP molecules to be part of a complex, which function to select peptides, protect them from degradation, and facilitate their translocation by targeting them to the ER membrane.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1044-5323
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-16
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Early events in the assembly of MHC class I antigens.
pubmed:affiliation
Ludwig Institute for Cancer Research, Stockholm Branch, Sweden.
pubmed:publicationType
Journal Article, Review