| pubmed-article:8496666 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8496666 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:8496666 | lifeskim:mentions | umls-concept:C1882878 | lld:lifeskim |
| pubmed-article:8496666 | lifeskim:mentions | umls-concept:C1141639 | lld:lifeskim |
| pubmed-article:8496666 | lifeskim:mentions | umls-concept:C0008385 | lld:lifeskim |
| pubmed-article:8496666 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:8496666 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8496666 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8496666 | pubmed:dateCreated | 1993-6-23 | lld:pubmed |
| pubmed-article:8496666 | pubmed:abstractText | Hormone-sensitive lipase (HSL) is an intracellular neutral lipase found in a variety of tissues, primarily in adipose and steroidogenic tissues, that hydrolyzes triglycerides and cholesteryl esters. In the rat testis steady-state levels of HSL mRNA increase dramatically during sexual maturation. In addition, HSL-like immunoreactive proteins of 84, -89, and -102 kD have been observed in sexually immature rats with additional -113 and -127 kD immunoreactive proteins expressed in mature animals. In the present studies the ability of human chorionic gonadotropin (hCG) to regulate the expression of HSL and HSL-like immunoreactive proteins in rat testes has been examined. Treatment of sexually immature rats with daily injections of hCG caused a gradual increase in HSL activity that reached an 80% rise (P < 0.01) after 5 days. This was paralleled by a 3-fold increase (P < 0.01) in the 84 kD protein representing the active HSL enzyme. The -89 kD immunoreactive protein was also increased -5-fold (P < 0.01) in parallel to the 84 kD protein and HSL activity. The -102 kD immunoreactive protein was increased by hCG treatment (P < 0.01); however, its expression did not follow changes in HSL activity or in the 84 and -89 kD immunoreactive proteins, peaking within 12 h and declining thereafter. The -113 and -127 kD immunoreactive proteins did not appear during the 5 days of hCG treatment. Steady-state levels of HSL mRNA increased 60-100% (P < 0.02) in parallel to the changes in HSL activity and in the 84 and -89 kD immunoreactive proteins.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:8496666 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8496666 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8496666 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8496666 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8496666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8496666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8496666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8496666 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8496666 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8496666 | pubmed:issn | 0022-2275 | lld:pubmed |
| pubmed-article:8496666 | pubmed:author | pubmed-author:PatelSS | lld:pubmed |
| pubmed-article:8496666 | pubmed:author | pubmed-author:KraemerF BFB | lld:pubmed |
| pubmed-article:8496666 | pubmed:author | pubmed-author:SztalrydCC | lld:pubmed |
| pubmed-article:8496666 | pubmed:author | pubmed-author:SaediM SMS | lld:pubmed |
| pubmed-article:8496666 | pubmed:author | pubmed-author:Singh-BistAA | lld:pubmed |
| pubmed-article:8496666 | pubmed:author | pubmed-author:GholamiS SSS | lld:pubmed |
| pubmed-article:8496666 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8496666 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:8496666 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8496666 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8496666 | pubmed:pagination | 609-16 | lld:pubmed |
| pubmed-article:8496666 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8496666 | pubmed:meshHeading | pubmed-meshheading:8496666-... | lld:pubmed |
| pubmed-article:8496666 | pubmed:meshHeading | pubmed-meshheading:8496666-... | lld:pubmed |
| pubmed-article:8496666 | pubmed:meshHeading | pubmed-meshheading:8496666-... | lld:pubmed |
| pubmed-article:8496666 | pubmed:meshHeading | pubmed-meshheading:8496666-... | lld:pubmed |
| pubmed-article:8496666 | pubmed:meshHeading | pubmed-meshheading:8496666-... | lld:pubmed |
| pubmed-article:8496666 | pubmed:meshHeading | pubmed-meshheading:8496666-... | lld:pubmed |
| pubmed-article:8496666 | pubmed:meshHeading | pubmed-meshheading:8496666-... | lld:pubmed |
| pubmed-article:8496666 | pubmed:meshHeading | pubmed-meshheading:8496666-... | lld:pubmed |
| pubmed-article:8496666 | pubmed:meshHeading | pubmed-meshheading:8496666-... | lld:pubmed |
| pubmed-article:8496666 | pubmed:meshHeading | pubmed-meshheading:8496666-... | lld:pubmed |
| pubmed-article:8496666 | pubmed:meshHeading | pubmed-meshheading:8496666-... | lld:pubmed |
| pubmed-article:8496666 | pubmed:meshHeading | pubmed-meshheading:8496666-... | lld:pubmed |
| pubmed-article:8496666 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8496666 | pubmed:articleTitle | Detection of hormone-sensitive lipase in various tissues. II. Regulation in the rat testis by human chorionic gonadotropin. | lld:pubmed |
| pubmed-article:8496666 | pubmed:affiliation | Veterans Administration Medical Center, Palo Alto, CA 94304. | lld:pubmed |
| pubmed-article:8496666 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8496666 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8496666 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8496666 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8496666 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8496666 | lld:pubmed |
