Linked Life Data

8496338

Source:http://linkedlifedata.com/resource/pubmed/id/8496338

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-6-22
pubmed:abstractText
A variety of stressors have been shown to influence specific and non-specific measures of immune function in laboratory animals. One of the most common tools used to evaluate lymphocyte function is the non-specific mitogen proliferation assay. Assessment of this function in the rat spleen has revealed profound suppression following restraint, electric shock, and re-exposure of animals to a fearful context. However, there have been no studies that have compared the effects of stressor exposure on mitogen- and specific antigen-stimulated spleen cell proliferation. Therefore, the present study addressed this issue through experiments in which rats were immunized intraperitoneally with 1 microgram cholera toxin and exposed to acute (one session) or repeated (three consecutive daily sessions) footshock. The results showed that footshock exposure prior to immunization inhibited cholera toxin stimulated spleen cell proliferation 7 days after immunization. Acute or repeated footshock exposure 5-7 days after cholera toxin immunization depressed non-specific spleen cell proliferation, while augmenting the proliferative response to specific antigen. From these observations it can be hypothesized that footshock exposure either differentially regulates lymphocyte activation by clonal and polyclonal signals, and/or naive and memory cells react differently to stressor exposure.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0165-5728
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-42
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Inescapable footshock exposure differentially alters antigen- and mitogen-stimulated spleen cell proliferation in rats.
pubmed:affiliation
Brain, Behavior and Immunity Center, University of Pittsburgh School of Medicine.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't