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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-6-21
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pubmed:abstractText |
1. In the guinea-pig ileum the C-terminal hexapeptide of the endothelins, endothelin (16-21), induced a biphasic effect (relaxation followed by contraction) qualitatively similar to that seen in the responses to endothelins 1 and 3. Both components of the response were concentration-dependent in the range studied (2-100 microM). 2. The response induced by endothelin (16-21) was inhibited in low-sodium (80 mM) medium. 3. Repeated administration of endothelin (16-21) induced no desensitization of the preparation, contrasting with the tachyphylaxis induced by endothelin-1 and endothelin-3 in the guinea-pig ileum. 4. Tissues rendered tachyphylatic to endothelin-1 or endothelin-3 responded normally to endothelin (16-21). 5. The results suggest that the C-terminal tail of the endothelins contains the message for the biphasic response, whereas the N-terminal domain may be responsible for the strong binding to the receptor and for the tachyphylactic properties of endothelin-1 and endothelin-3, in the guinea-pig isolated ileum. However, the possibility that endothelin (16-21) may be acting on a site other than the endothelin receptor cannot be ruled out.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-1310132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-1325352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-1648907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-1659115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-1725433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-1847589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-1915577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-1965732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-2072309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-2118569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-2282462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-2451132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-2540744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-2553427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-2690429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-2693125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-2768235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-2845579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-3056409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-4358432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8495248-7122224
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
68-72
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8495248-Amino Acid Sequence,
pubmed-meshheading:8495248-Animals,
pubmed-meshheading:8495248-Endothelins,
pubmed-meshheading:8495248-Female,
pubmed-meshheading:8495248-Guinea Pigs,
pubmed-meshheading:8495248-Ileum,
pubmed-meshheading:8495248-Isometric Contraction,
pubmed-meshheading:8495248-Male,
pubmed-meshheading:8495248-Molecular Sequence Data,
pubmed-meshheading:8495248-Muscle, Smooth,
pubmed-meshheading:8495248-Peptide Fragments,
pubmed-meshheading:8495248-Receptors, Endothelin,
pubmed-meshheading:8495248-Sodium,
pubmed-meshheading:8495248-Tachyphylaxis
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pubmed:year |
1993
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pubmed:articleTitle |
Endothelin (16-21): biphasic effect and no desensitization on the guinea-pig isolated ileum.
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pubmed:affiliation |
Department of Biophysics, Escola Paulista de Medicina, SP, Brazil.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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