Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1993-6-11
|
| pubmed:abstractText |
The prognostic significance of expression of myeloid-associated antigens in childhood acute lymphoblastic leukemia (myA+ALL) was evaluated. From 1984 to 1990, 251 children with immunologically verified ALL were treated in two prospective consecutive Austrian studies. Complete immunophenotyping was performed in 206 cases (82%). Out of these 175 cases were classified as B-cell precursor ALL, 31 cases as T-ALL. Expression of myeloid-associated antigens was demonstrated in 23 cases (13.1%) of childhood B-cell precursor ALL, particularly in immature (CD10 negative) forms (P < .0001), and in 1 case (3.2%) of T-ALL. CDw65 was expressed most frequently (12 cases), followed by CD13 and CD15 (5 cases each), CD33 (4 cases), and blood-group H (3 cases). Compared to myA- ALL prognosis of children with myA+ B-cell precursor ALL was poor, despite intensive multiagent chemotherapy according to BFM protocols. Remission rates were not impaired, but pEFS was 74.6% for myA- ALL, and only 37.8% for myA+ ALL (P = .0001). As demonstrated by multivariate analysis the expression of myeloid-associated antigens was the most important prognostic variable for EFS in B-cell precursor ALL, whether or not CD10 was expressed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0098-1532
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
340-6
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8492748-Adolescent,
pubmed-meshheading:8492748-Antigens, CD15,
pubmed-meshheading:8492748-Antigens, Neoplasm,
pubmed-meshheading:8492748-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:8492748-Child,
pubmed-meshheading:8492748-Cranial Irradiation,
pubmed-meshheading:8492748-Hemoglobins,
pubmed-meshheading:8492748-Humans,
pubmed-meshheading:8492748-Immunophenotyping,
pubmed-meshheading:8492748-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:8492748-Leukocytes,
pubmed-meshheading:8492748-Multivariate Analysis,
pubmed-meshheading:8492748-Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:8492748-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:8492748-Predictive Value of Tests,
pubmed-meshheading:8492748-Prognosis,
pubmed-meshheading:8492748-Prospective Studies,
pubmed-meshheading:8492748-Treatment Outcome,
pubmed-meshheading:8492748-Tumor Markers, Biological
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Prognostic significance of myeloid-associated antigen expression on blast cells in children with acute lymphoblastic leukemia. The Austrian Pediatric Oncology Group.
|
| pubmed:affiliation |
St. Anna Children's Hospital, Vienna, Austria.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|