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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
22
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pubmed:dateCreated |
1993-6-17
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pubmed:abstractText |
The antidepressant-like effect of 8-hydroxy-2-(di-n-propylamino)tetralin(8-OH-DPAT), a selective 5-HT1A receptor agonist, was studied in the forced swimming wheel test in reserpine-treated mice. 8-OH-DPAT and the antidepressant imipramine, dose-dependently increased the number of turns of a water wheel made by mice. This effect of imipramine (30 mg/kg, i.p.) was enhanced by reserpine treatment 24 hr before the test. The effect of 8-OH-DPAT (0.3 mg/kg, i.p.) was also enhanced in reserpine-treated mice. This enhanced effect of 8-OH-DPAT was blocked by pretreatment with the 5-HT1A receptor antagonists, (-)-propranolol (3 mg/kg, i.p.) and NAN-190 (1 mg/kg, i.p.), but was not blocked by a beta-blocker, (-)-atenolol (3 mg/kg, i.p.). 8-OH-DPAT did not affect locomotor activity in the reserpinized mice and did not affect the reduction of monoamine content induced by reserpine. These results suggest that the effect of 8-OH-DPAT in increasing the number of turns of the wheel made by mice was exerted through a 5-HT1A receptor and that this effect did not reflect only changes in the locomotor activity of the mice.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral...,
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Imipramine,
http://linkedlifedata.com/resource/pubmed/chemical/Propranolol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Reserpine
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pubmed:status |
MEDLINE
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pubmed:issn |
0024-3205
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1741-9
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:8492637-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:8492637-Animals,
pubmed-meshheading:8492637-Antidepressive Agents,
pubmed-meshheading:8492637-Dose-Response Relationship, Drug,
pubmed-meshheading:8492637-Drug Interactions,
pubmed-meshheading:8492637-Imipramine,
pubmed-meshheading:8492637-Male,
pubmed-meshheading:8492637-Mice,
pubmed-meshheading:8492637-Mice, Inbred ICR,
pubmed-meshheading:8492637-Motor Activity,
pubmed-meshheading:8492637-Propranolol,
pubmed-meshheading:8492637-Receptors, Serotonin,
pubmed-meshheading:8492637-Reserpine,
pubmed-meshheading:8492637-Swimming
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pubmed:year |
1993
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pubmed:articleTitle |
Role of 5-HT1A receptors in the forced swimming wheel test in reserpine-treated mice.
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pubmed:affiliation |
First Lab. for Pharmacological Research, Asahi Chemical Industry Co., Ltd., Miyazaki, Japan.
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pubmed:publicationType |
Journal Article
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