pubmed-article:8470427 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8470427 | lifeskim:mentions | umls-concept:C0035236 | lld:lifeskim |
pubmed-article:8470427 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
pubmed-article:8470427 | lifeskim:mentions | umls-concept:C0042736 | lld:lifeskim |
pubmed-article:8470427 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
pubmed-article:8470427 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
pubmed-article:8470427 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
pubmed-article:8470427 | pubmed:issue | 4 | lld:pubmed |
pubmed-article:8470427 | pubmed:dateCreated | 1993-5-7 | lld:pubmed |
pubmed-article:8470427 | pubmed:abstractText | Mice were infected with respiratory syncytial (RS) virus or with recombinant vaccinia viruses (rVV) expressing individual RS virus proteins. rVV-G, rVV-F and, to a lesser extent, rVV-P induced ELISA-binding anti-RS virus antibodies; those induced by rVV-P were non-neutralizing. Different antigens induced helper T cells with distinct cytokine secretion profiles: some released IL-2, and others predominantly IL-4 and 5. Virus-specific cytotoxicity was induced by infection with RS virus, rVV-F or rVV-22K. Different RS virus proteins (given in the same route and form) therefore prime for functionally distinct T-cell activities. These patterns of virus-specific immunity may help explain the pathogenicity of RS virus vaccines, and help in the design of protective, non-pathogenic vaccines in the future. | lld:pubmed |
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pubmed-article:8470427 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8470427 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:8470427 | pubmed:language | eng | lld:pubmed |
pubmed-article:8470427 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8470427 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:8470427 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8470427 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8470427 | pubmed:issn | 0264-410X | lld:pubmed |
pubmed-article:8470427 | pubmed:author | pubmed-author:OpenshawP JPJ | lld:pubmed |
pubmed-article:8470427 | pubmed:author | pubmed-author:AlwanW HWH | lld:pubmed |
pubmed-article:8470427 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8470427 | pubmed:volume | 11 | lld:pubmed |
pubmed-article:8470427 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8470427 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8470427 | pubmed:pagination | 431-7 | lld:pubmed |
pubmed-article:8470427 | pubmed:dateRevised | 2009-9-29 | lld:pubmed |
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pubmed-article:8470427 | pubmed:year | 1993 | lld:pubmed |
pubmed-article:8470427 | pubmed:articleTitle | Distinct patterns of T- and B-cell immunity to respiratory syncytial virus induced by individual viral proteins. | lld:pubmed |
pubmed-article:8470427 | pubmed:affiliation | Department of Medicine, St Mary's Hospital Medical School, London, UK. | lld:pubmed |
pubmed-article:8470427 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:8470427 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:8470427 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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