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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1993-5-4
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pubmed:databankReference |
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pubmed:abstractText |
Eukaryotic translation initiation factor 5 (eIF-5) catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.AUG.Met-tRNAf-eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the formation of a functional 80S initiation complex. A rat cDNA that encodes eIF-5 has been isolated and expressed in Escherichia coli to yield a catalytically active eIF-5 protein. The 3.55-kb cDNA encodes a protein of 429 amino acids (calculated M(r) 48,926) with properties that are similar to eIF-5 isolated from rabbit reticulocyte lysates. The deduced amino acid sequence of eIF-5 contains sequence motifs characteristic of proteins of the GTPase superfamily.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-1095581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-1620067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-1856230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-1883206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-1898771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-1955461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-1970792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-2199796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-2440886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-2448583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-2449095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-272635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-2784437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-2820998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-2925684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-3844405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-3844406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-468782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-592398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-6343825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-641055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-6546423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-6583673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-7051967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464924-7451444
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Eukaryotic Initiation Factor-5,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Initiation Factors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Transfer, Amino Acyl,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Transfer, Met,
http://linkedlifedata.com/resource/pubmed/chemical/tRNA, formylmethionine-
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3058-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8464924-Amino Acid Sequence,
pubmed-meshheading:8464924-Animals,
pubmed-meshheading:8464924-Base Sequence,
pubmed-meshheading:8464924-Cloning, Molecular,
pubmed-meshheading:8464924-DNA,
pubmed-meshheading:8464924-Escherichia coli,
pubmed-meshheading:8464924-Eukaryotic Initiation Factor-5,
pubmed-meshheading:8464924-GTP Phosphohydrolases,
pubmed-meshheading:8464924-Guanosine Triphosphate,
pubmed-meshheading:8464924-Liver,
pubmed-meshheading:8464924-Macromolecular Substances,
pubmed-meshheading:8464924-Molecular Sequence Data,
pubmed-meshheading:8464924-Multigene Family,
pubmed-meshheading:8464924-Oligodeoxyribonucleotides,
pubmed-meshheading:8464924-Peptide Initiation Factors,
pubmed-meshheading:8464924-Protein Biosynthesis,
pubmed-meshheading:8464924-RNA, Transfer, Amino Acyl,
pubmed-meshheading:8464924-RNA, Transfer, Met,
pubmed-meshheading:8464924-Rabbits,
pubmed-meshheading:8464924-Restriction Mapping,
pubmed-meshheading:8464924-Reticulocytes,
pubmed-meshheading:8464924-Ribosomes,
pubmed-meshheading:8464924-Sequence Homology, Amino Acid
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pubmed:year |
1993
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pubmed:articleTitle |
Molecular cloning and expression of cDNA for mammalian translation initiation factor 5.
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pubmed:affiliation |
Department of Developmental Biology and Cancer, Albert Einstein College of Medicine, Bronx, NY 10461.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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