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pubmed-article:8458819pubmed:abstractTextWe evaluated the contribution of measurement errors in PO2 to the discrepancy between the intrapulmonary shunt values simultaneously obtained by the conventional O2 method (O2-shunt) and the multiple inert gas elimination technique (IG-shunt). Excised left lower lobes of dogs were perfused at a constant flow and ventilated at constant volume. Variable degrees of intrapulmonary shunt were created by O2 absorption while the lobes were collapsed. IG-shunt ranged from 0 to 66%. Although the O2-shunt and IG-shunt values correlated well (r = 0.97), the slope was only 0.74 and the regression line crossed the line of identity at 12% IG-shunt. The gas-to-blood ratio of the oxygen electrode was constant over the range 80-687 Torr and therefore did not seem to be an important factor in the shunt discrepancy. Errors due to nonlinearity of the O2 electrode also had only a minor effect. However, PO2 history of the electrode just before injection of blood samples into the cuvette had a profound and complex effect on the measured PO2. We conclude that PO2 electrode hysteresis can be a major factor in the wide variability of PO2 measurements and could account for most of the differences between our O2-shunt and IG-shunt data.lld:pubmed
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pubmed-article:8458819pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:8458819pubmed:year1993lld:pubmed
pubmed-article:8458819pubmed:articleTitleIntrapulmonary shunt in excised dog lobes: comparison of oxygen and inert gas methods.lld:pubmed
pubmed-article:8458819pubmed:affiliationFirst Department of Internal Medicine, Yamagata University School of Medicine, Japan.lld:pubmed
pubmed-article:8458819pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8458819pubmed:publicationTypeComparative Studylld:pubmed
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pubmed-article:8458819pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed