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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-4-27
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pubmed:abstractText |
The purpose of this study was to determine whether short-term training cessation resulted in reduced GLUT-4 protein levels. Endurance- (n = 12, ET) and strength-trained (n = 12) individuals (ST) were examined before and after 14 days of training withdrawal. GLUT-4 content was determined from muscle biopsy samples of the gastrocnemius in ET and the vastus lateralis in ST. Insulin sensitivity (oral glucose tolerance test) was significantly (P < 0.05) reduced in ET and ST with training cessation. GLUT-4 content was unaltered (P > 0.05) in both groups (92 and 100% of trained values for ET and ST, respectively). In ET, citrate synthase activity decreased significantly (P < 0.05) with training withdrawal (41.0 +/- 3.6 vs. 30.6 +/- 2.8 mumol.g-1.min-1); in ST no change was evident. The decrement in insulin sensitivity with the cessation of endurance- or resistance-oriented activity is therefore not associated with a reduction in GLUT-4 protein content. Muscle oxidative capacity and GLUT-4 content do not coincide with the removal of endurance training.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
8750-7587
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
776-81
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8458795-Adult,
pubmed-meshheading:8458795-Body Composition,
pubmed-meshheading:8458795-Citrate (si)-Synthase,
pubmed-meshheading:8458795-Female,
pubmed-meshheading:8458795-Glucose Tolerance Test,
pubmed-meshheading:8458795-Glucose Transporter Type 4,
pubmed-meshheading:8458795-Humans,
pubmed-meshheading:8458795-Insulin,
pubmed-meshheading:8458795-Male,
pubmed-meshheading:8458795-Monosaccharide Transport Proteins,
pubmed-meshheading:8458795-Muscle Proteins,
pubmed-meshheading:8458795-Muscles,
pubmed-meshheading:8458795-Physical Education and Training,
pubmed-meshheading:8458795-Physical Endurance,
pubmed-meshheading:8458795-Physical Exertion,
pubmed-meshheading:8458795-Physical Fitness,
pubmed-meshheading:8458795-Running,
pubmed-meshheading:8458795-Weight Lifting
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pubmed:year |
1993
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pubmed:articleTitle |
Training cessation does not alter GLUT-4 protein levels in human skeletal muscle.
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pubmed:affiliation |
Human Performance Laboratory, School of Medicine, East Carolina University, Greenville, North Carolina 27858.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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