Linked Life Data

8450739

Source:http://linkedlifedata.com/resource/pubmed/id/8450739

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-4-12
pubmed:abstractText
The oxygen dependencies of the 19F NMR spin-lattice relaxation rates (R1 = 1/T1) of a perfluorocarbon emulsion sequestered in a murine tumor model has been used to evaluate nicotinamide, a radiosensitizer believed to act through enhanced tissue oxygenation. Fluorine-19 NMR spectroscopic measurements from solid Radiation-Induced Fibrosarcoma (RIF-1) tumors in C3H mice showed a statistically significant improvement in tumor pO2 for a Nicotinamide-treated group, with a delta pO2 = 4.7 +/- 3 torr ( = mm Hg) (Mean +/- SEM) at t = 60 min (P < .01), and 4.5 +/- 3 at t = 70 min post intraperitoneal injection (P < 0.02) as compared with saline-treated Controls, while several other time points for which t > 30 min were significant at the P < 0.05 level. Both groups had n = 10, and the statistics were based on Student's one-tailed group t test. By comparison, in another study group where breathing gas was switched from air to 100% O2, a statistically insignificant increase of 2 torr was realized in tumor pO2 (n = 9). The maximal treatment effect occurs at a delay of 60 to 70 min, consistent with results obtained by other investigators using radiobiology techniques. Fluorine-19 spectroscopic relaxometry can measure therapeutically meaningful changes in in vivo tumor pO2 and represents an improvement in expenditures of time, animal resources, and statistical power over conventional radiobiological methods.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0740-3194
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-10
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Assessment of changes in murine tumor oxygenation in response to nicotinamide using 19F NMR relaxometry of a perfluorocarbon emulsion.
pubmed:affiliation
Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't