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pubmed-article:8449224pubmed:abstractTextRats suffering from experimental autoimmune myasthenia gravis (EAMG) induced by previous immunization with foreign acetylcholine receptor (AChR) were treated with AChR-toxin conjugates using the plant toxin gelonin. This led to a marked improvement of clinical symptoms as well as a significant increase in functional AChR compared to untreated rats with EAMG as determined 6 to 10 weeks later. No therapeutic effect was observed after treatment with gelonin or AChR alone. The immune response to irrelevant control antigens was not altered by this treatment.lld:pubmed
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pubmed-article:8449224pubmed:articleTitleAntigen-specific therapy of experimental myasthenia gravis with acetylcholine receptor-gelonin conjugates in vivo.lld:pubmed
pubmed-article:8449224pubmed:affiliationFachbereich Chemie, Universität Kaiserslautern, FRG.lld:pubmed
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