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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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pubmed:dateCreated |
1993-4-13
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pubmed:abstractText |
Rats suffering from experimental autoimmune myasthenia gravis (EAMG) induced by previous immunization with foreign acetylcholine receptor (AChR) were treated with AChR-toxin conjugates using the plant toxin gelonin. This led to a marked improvement of clinical symptoms as well as a significant increase in functional AChR compared to untreated rats with EAMG as determined 6 to 10 weeks later. No therapeutic effect was observed after treatment with gelonin or AChR alone. The immune response to irrelevant control antigens was not altered by this treatment.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-2980
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
23
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
776-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8449224-Animals,
pubmed-meshheading:8449224-Autoantibodies,
pubmed-meshheading:8449224-Female,
pubmed-meshheading:8449224-Immunotoxins,
pubmed-meshheading:8449224-Myasthenia Gravis,
pubmed-meshheading:8449224-Plant Proteins,
pubmed-meshheading:8449224-Rats,
pubmed-meshheading:8449224-Rats, Sprague-Dawley,
pubmed-meshheading:8449224-Receptors, Nicotinic,
pubmed-meshheading:8449224-Ribosome Inactivating Proteins, Type 1
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pubmed:year |
1993
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|
pubmed:articleTitle |
Antigen-specific therapy of experimental myasthenia gravis with acetylcholine receptor-gelonin conjugates in vivo.
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|
pubmed:affiliation |
Fachbereich Chemie, Universität Kaiserslautern, FRG.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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