| pubmed-article:8441394 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8441394 | lifeskim:mentions | umls-concept:C0079784 | lld:lifeskim |
| pubmed-article:8441394 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:8441394 | lifeskim:mentions | umls-concept:C0020291 | lld:lifeskim |
| pubmed-article:8441394 | lifeskim:mentions | umls-concept:C1959616 | lld:lifeskim |
| pubmed-article:8441394 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8441394 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:8441394 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:8441394 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8441394 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8441394 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8441394 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8441394 | pubmed:dateCreated | 1993-4-1 | lld:pubmed |
| pubmed-article:8441394 | pubmed:abstractText | Stimulation of diglyceride production via phospholipase C (PLC) hydrolysis of phosphatidylcholine was an early event in the mitogenic action of colony-stimulating factor 1 (CSF-1) in the murine macrophage cell line BAC1.2F5 and was followed by a second phase of diglyceride production that persisted throughout the G1 phase of the cell cycle. Addition of phosphatidylcholine-specific PLC (PC-PLC) from Bacillus cereus to the medium of quiescent cells raised the intracellular diglyceride concentration and stimulated [3H]thymidine incorporation, although PC-PLC did not support continuous proliferation. PC-PLC treatment did not induce tyrosine phosphorylation or turnover of the CSF-1 receptor. The major protein kinase C (PKC) isotype in BAC1.2F5 cells was PKC-delta. Diglyceride production from PC-PLC did not target PKC-delta, since unlike phorbol esters, PC-PLC treatment neither decreased the electrophoretic mobility of PKC-delta nor increased the amount of GTP bound to Ras, and PC-PLC was mitogenically active in BAC1.2F5 cells in which PKC-delta was downregulated by prolonged treatment with phorbol ester. PC-PLC mimicked CSF-1 action by elevating c-fos and junB mRNAs to 40% of the level induced by CSF-1; however, PC-PLC induced c-myc mRNA to only 5% of the level in CSF-1-stimulated cells. PC-PLC addition to CSF-1-dependent BAC1.2F5 clones that constitutively express c-myc increased [3H]thymidine incorporation to 86% of the level evoked by CSF-1 and supported slow growth in the absence of CSF-1. Therefore, PC-PLC is a component of a signal transduction pathway leading to transcription of c-fos and junB that collaborates with c-myc and is independent of PKC-delta and Ras activation. | lld:pubmed |
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| pubmed-article:8441394 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8441394 | pubmed:citationSubset | IM | lld:pubmed |
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