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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-3-25
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pubmed:abstractText |
A daunorubicin-blocked mutant strain RPM-5 derived from a new baumycin-producing Streptomyces sp. D788 accumulated a major precursor metabolite D788-1 (10-carboxyl-13-deoxocarminomycin) and nine minor metabolites in the culture broth. Five among them were new with a substituent at C-10 or the altered side chains at C-9. Isolation, purification and identification of all anthracycline metabolites produced by strain RPM-5 are described with their antitumor activities against L1210 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
56-64
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:8436560-Animals,
pubmed-meshheading:8436560-Antibiotics, Antineoplastic,
pubmed-meshheading:8436560-Carubicin,
pubmed-meshheading:8436560-DNA, Neoplasm,
pubmed-meshheading:8436560-DNA Replication,
pubmed-meshheading:8436560-Daunorubicin,
pubmed-meshheading:8436560-Fermentation,
pubmed-meshheading:8436560-Leukemia L1210,
pubmed-meshheading:8436560-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8436560-Mice,
pubmed-meshheading:8436560-RNA, Neoplasm,
pubmed-meshheading:8436560-Streptomyces,
pubmed-meshheading:8436560-Tumor Cells, Cultured
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pubmed:year |
1993
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pubmed:articleTitle |
Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. II. New anthracycline metabolites produced by a blocked mutant strain RPM-5.
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pubmed:affiliation |
Central Research Laboratories, Mercian Corporation, Kanagawa, Japan.
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pubmed:publicationType |
Journal Article
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