Linked Life Data

8434537

Source:http://linkedlifedata.com/resource/pubmed/id/8434537

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-3-15
pubmed:abstractText
The authors performed neonatal healthy retinal pigment epithelium (RPE) transplantation into older eyes to test whether aging changes could be deterred or arrested in an appropriate model. Fischer-344 rats, a model for studying age-related photoreceptor cell death, were used as the recipient and 6- to 8-day-old Long Evans rats were used as the donor of neonatal RPE. Isolated RPE cells were transplanted into the subretinal space in 24, 3-month-old Fischer-344 rats. The presence of healthy neonatal RPE cells significantly maintained the thickness of each layer as compared to the findings in nongrafted and sham operated controls at 3 and 6 months after the transplantation. The transplanted RPE cells saved the reduction of cell population caused by aging from 40% to 17% in the outer nuclear layer and from 33% to 8% in the inner nuclear layer at 6 months after transplantation.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0029-0203
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
36-42
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Effect of neonatal retinal pigment cell transplantation on aged retinas].
pubmed:affiliation
Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.
pubmed:publicationType
Journal Article, English Abstract