Linked Life Data

8434460

Source:http://linkedlifedata.com/resource/pubmed/id/8434460

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-3-18
pubmed:abstractText
The effects of prenatal exposure to 13.78 mg, 27.56 mg or 82.6 mg malathion/100 g body weight po from 6-13 d of gestation, to 1 microgram estradiol-17-beta/d/100g body weight or 4 mg progesterone/d/100 g body weight sc from 3-20 d of gestation, or to their various combinations on brain acetylcholinesterase activity and ascorbic acid metabolism were investigated in rat dams and pups. Brain acetylcholinesterase activity was taken as an index of toxicity. Significant inhibition of acetylcholinesterase from malathion exposure was further exaggerated by estradiol-17-beta, but was reversed by progesterone. Significant increases of ascorbic acid levels and L-gulonolactone oxidase was observed with malathion toxicity. Estradiol-17-beta decreased ascorbic acid levels and stimulated dehydroascorbatase, while progesterone had no significant effect on ascorbic acid levels or on enzyme activities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0145-6296
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effect of malathion, estradiol-17-beta and progesterone on ascorbic acid metabolism in prenatal rats and their pups.
pubmed:affiliation
Department of Biochemistry, University of Kerala, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't