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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-3-5
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pubmed:databankReference |
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pubmed:abstractText |
In that salmonellae have been implicated in an unprecedented array of diseases, sequences found to be specific to this species are often thought to be involved in the virulence attributes not seen in other enteric bacteria. To identify the molecular, genetic, and phenotypic characteristics that differentiate bacterial species, we analyzed five cloned DNA fragments that were originally described as being confined to Salmonella. Most of these segments mapped to unique positions on the Salmonella typhimurium chromosome indicative of independent evolutionary events, and three had G+C contents considerably lower than that of the Salmonella genome, suggesting that they arose through horizontal transfer. The nucleotide sequence was determined for one of the clones exhibiting an atypical base composition. This 4.9-kb fragment contained an open reading frame with structural similarity to the LysR family of transcriptional regulators. Strains harboring deletions in this region were tested for > 120 phenotypic characteristics including the effects on a collection of environmentally regulated lac gene fusions. In addition, all deletion strains behaved like the wild-type parent when tested for virulence in mice.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-1090005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-1311301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-1311853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-1339343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-1367316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-1530848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-16453650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-1833723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-1879916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-1907267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-1943705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-1955870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2087223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2180148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2183352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2203756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2403541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2543631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2544889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2548211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2646710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2662196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2666399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2674945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2793832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2793833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-2919285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-3009420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-3020001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-3036774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-3070321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-3316029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-3467347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-3512523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-3523484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-368646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-6251543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-6355392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8430070-6546423
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
90
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pubmed:geneSymbol |
sinR
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1033-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8430070-Amino Acid Sequence,
pubmed-meshheading:8430070-Base Composition,
pubmed-meshheading:8430070-Base Sequence,
pubmed-meshheading:8430070-Biological Evolution,
pubmed-meshheading:8430070-Cloning, Molecular,
pubmed-meshheading:8430070-DNA Mutational Analysis,
pubmed-meshheading:8430070-Genes, Bacterial,
pubmed-meshheading:8430070-Genes, Regulator,
pubmed-meshheading:8430070-Molecular Sequence Data,
pubmed-meshheading:8430070-Open Reading Frames,
pubmed-meshheading:8430070-Phylogeny,
pubmed-meshheading:8430070-Salmonella,
pubmed-meshheading:8430070-Sequence Homology, Amino Acid,
pubmed-meshheading:8430070-Species Specificity,
pubmed-meshheading:8430070-Virulence
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pubmed:year |
1993
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pubmed:articleTitle |
Molecular, functional, and evolutionary analysis of sequences specific to Salmonella.
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pubmed:affiliation |
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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