Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1993-3-4
|
pubmed:abstractText |
This randomized study compares the coronary perfusion rate in patients with acute myocardial infarction (AMI) treated with 2 different intravenous thrombolytic agents: streptokinase 1.5 million U given over 60 minutes and anisoylated human plasminogen streptokinase activator complex (anistreplase) administrated as a bolus of 30 U over 5 minutes. One hundred seventy-five patients (149 men and 26 women, mean age 54 years) have been included in this study. Eighty-nine patients were treated with anistreplase and 86 patients with streptokinase. AMI was inferior in 54 patients (61%) in the anistreplase group and in 54 patients (63%) in the streptokinase group. It was anterior in 35 (40%) and 32 (37%) patients, respectively. Coronary angiography and ventriculography were performed at a mean time (+/- SEM) of 207 +/- 11 minutes after the beginning of thrombolysis in 170 patients. A perfusion score grade of 2 or 3 according to the Thrombolysis in Myocardial Infarction trial was found in 63 patients (72%) in the anistreplase group and in 56 patients (68%) in the streptokinase group (p = NS). Severe bleeding occurred in 7 patients (8%) after anistreplase and in 6 patients (7%) after streptokinase. No cerebral hemorrhage occurred. Nine patients (5%) died during their hospital stay: 6 after anistreplase and 3 after streptokinase. It is concluded that intravenous administration of anistreplase or streptokinase is efficient and safe. Coronary patency 207 minutes after fibrinolysis, incidence of adverse events and mortality are similar in both groups.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0002-9149
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
71
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
N
|
pubmed:pagination |
274-80
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8427167-Adult,
pubmed-meshheading:8427167-Aged,
pubmed-meshheading:8427167-Anistreplase,
pubmed-meshheading:8427167-Chi-Square Distribution,
pubmed-meshheading:8427167-Coronary Angiography,
pubmed-meshheading:8427167-Electrocardiography,
pubmed-meshheading:8427167-Female,
pubmed-meshheading:8427167-Humans,
pubmed-meshheading:8427167-Infusions, Intravenous,
pubmed-meshheading:8427167-Male,
pubmed-meshheading:8427167-Middle Aged,
pubmed-meshheading:8427167-Myocardial Infarction,
pubmed-meshheading:8427167-Regression Analysis,
pubmed-meshheading:8427167-Streptokinase,
pubmed-meshheading:8427167-Thrombolytic Therapy,
pubmed-meshheading:8427167-Time Factors
|
pubmed:year |
1993
|
pubmed:articleTitle |
Comparison of results of intravenous infusion of anistreplase versus streptokinase in acute myocardial infarction.
|
pubmed:affiliation |
Division de Cardiologie, Centre Hospitalier Universitaire, Lausanne, Switzerland.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|