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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6446
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pubmed:dateCreated |
1993-11-9
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pubmed:abstractText |
During T-cell development, site-specific DNA rearrangements mediating assembly of beta- and alpha-chain genes of the T-cell receptor (TCR) are developmentally ordered. In particular, assembly and expression of a complete beta-chain gene blocks further rearrangements at the beta-locus (a process referred to as allelic exclusion) and drives the generation and expansion of CD4+8+ cells. Although the mechanism used by TCR beta chains to deliver such signals is unknown, studies in transgenic animals have suggested that the lymphocyte-specific protein tyrosine kinase p56lck may impinge on a similar signalling pathway. The hypothesis that TCR beta chains deliver intracellular signals via p56lck makes an explicit prediction: that interference with p56lck function will mitigate the effects of a simultaneously expressed TCR beta chain. Here we confirm this prediction through examination of allelic exclusion in mice expressing both a functional TCR beta chain transgene and a catalytically inactive form of p56lck.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
365
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
552-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8413611-Alleles,
pubmed-meshheading:8413611-Animals,
pubmed-meshheading:8413611-Antigens, CD4,
pubmed-meshheading:8413611-Antigens, CD8,
pubmed-meshheading:8413611-Female,
pubmed-meshheading:8413611-Flow Cytometry,
pubmed-meshheading:8413611-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:8413611-Hematopoiesis, Extramedullary,
pubmed-meshheading:8413611-Lymphocyte Specific Protein Tyrosine Kinase p56(lck),
pubmed-meshheading:8413611-Male,
pubmed-meshheading:8413611-Mice,
pubmed-meshheading:8413611-Mice, Transgenic,
pubmed-meshheading:8413611-Polymerase Chain Reaction,
pubmed-meshheading:8413611-Protein-Tyrosine Kinases,
pubmed-meshheading:8413611-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8413611-Signal Transduction,
pubmed-meshheading:8413611-T-Lymphocyte Subsets,
pubmed-meshheading:8413611-Thymus Gland
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pubmed:year |
1993
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pubmed:articleTitle |
Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes.
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pubmed:affiliation |
Howard Hughes Medical Institute, University of Washington School of Medicine, SL-15, Seattle 98195.
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pubmed:publicationType |
Journal Article
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