| pubmed-article:8413234 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8413234 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:8413234 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8413234 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:8413234 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:8413234 | lifeskim:mentions | umls-concept:C1549781 | lld:lifeskim |
| pubmed-article:8413234 | lifeskim:mentions | umls-concept:C1710052 | lld:lifeskim |
| pubmed-article:8413234 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:8413234 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8413234 | pubmed:dateCreated | 1993-10-26 | lld:pubmed |
| pubmed-article:8413234 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8413234 | pubmed:abstractText | As is typical of Polycomb-group loci, the Enhancer of zeste [E(z)] gene negatively regulates the segment identity genes of the Antennapedia (ANT-C) and Bithorax (BX-C) gene complexes. A second class of loci, collectively known as the trithorax group, plays an antagonistic role as positive regulators of the ANT-C and BX-C genes. Molecular analysis of the E(z) gene predicts a 760-amino-acid protein product. A region of 116 amino acids near the E(z) carboxy terminus is 41.2% identical (68.4% similar) with a carboxy-terminal region of the trithorax protein. This portion of the trithorax protein is part of a larger region previously shown to share extensive homology with a human protein (ALL-1/Hrx) that is implicated in acute leukemias. Over this same 116 amino acids, E(z) and ALL-1/Hrx are 43.9% identical (68.4% similar). Otherwise, E(z) is not significantly similar to any previously described proteins. As this region of sequence similarity is shared by two proteins with antagonistic functions, we suggest that it may comprise a domain that interacts with a common target, either nucleic acid or protein. Opposite effects on transcription might then be determined by other portions of the two proteins. | lld:pubmed |
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| pubmed-article:8413234 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8413234 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8413234 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8413234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8413234 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8413234 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8413234 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:8413234 | pubmed:author | pubmed-author:JonesR SRS | lld:pubmed |
| pubmed-article:8413234 | pubmed:author | pubmed-author:GelbartW MWM | lld:pubmed |
| pubmed-article:8413234 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8413234 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:8413234 | pubmed:geneSymbol | trx | lld:pubmed |
| pubmed-article:8413234 | pubmed:geneSymbol | E(z) | lld:pubmed |
| pubmed-article:8413234 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8413234 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8413234 | pubmed:pagination | 6357-66 | lld:pubmed |
| pubmed-article:8413234 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
| pubmed-article:8413234 | pubmed:meshHeading | pubmed-meshheading:8413234-... | lld:pubmed |
| pubmed-article:8413234 | pubmed:meshHeading | pubmed-meshheading:8413234-... | lld:pubmed |
| pubmed-article:8413234 | pubmed:meshHeading | pubmed-meshheading:8413234-... | lld:pubmed |
