Linked Life Data

841185

Source:http://linkedlifedata.com/resource/pubmed/id/841185

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1977-4-15
pubmed:abstractText
To elucidate the initial steps of carcinogenesis by nickel subsulfide, the mechanisms of dissolution of alpha-Ni3S2 were studied by incubating alpha-Ni3S2 dust in (a) water, (b) rat serum, and (c) rat serum ultrafiltrate. The sediments that remained following incubation of alpha-Ni3S2 in the 3 media for 2 weeks were examined by X-ray diffractometry. The rates of solubilization of 63Ni from alpha-63Ni3S2 during incubation in the 3 media were measured by liquid scintillation counting. These studies showed that solubilization of Ni(II) from alpha-Ni3S2 in rat serum requires the presence of O2 and involves three reactions: [I] 2 alpha-Ni3S2 + O2 + 2H2O leads to 4 beta-NiS + 2Ni(OH)2; [ii] beta-NiS + 202 leads to Ni2+ + SO4(2-); and [III] Ni2+ & Ni(OH)2 + serum ligands [albumin & amino acids] leads to soluble Ni(II)-complexes. The rate of solubilization of 63Ni from alpha-63Ni3S2 was initially more rapid in rat serum than in serum ultrafiltrate and much more rapid than in water. After 2 days of incubation the rates of dissolution of alpha-63Ni3S2 in the 3 media became progressively retarded, probably owing to deposition of insoluble surface coatings of beta-63Nis and 63Ni(OH)2 on the alpha-63Ni3S2 particles.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-108
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Mechanisms of dissolution of nickel subsulfide in rat serum.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.