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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1993-11-24
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pubmed:abstractText |
The three type C retroviruses, gibbon ape leukemia virus (GALV), simian sarcoma-associated virus (SSAV), and feline leukemia virus subgroup B (FeLV-B), infect human cells by interacting with the same cell surface receptor, GLVR1. Using LacZ retroviral pseudotypes and murine cells transfected with mutant GLVR1 expression vectors, we show that the same 9-amino-acid region of human GLVR1 is critical for infection by the three viruses. Rat cells were not susceptible to infection by LacZ (FeLV-B) pseudotypes because of a block at the receptor level. We found multiple amino acid differences from human GLVR1 in the 9-amino-acid critical region of rat GLVR1. Expression of a human-rat chimeric GLVR1 in murine cells demonstrated that rat GLVR1 could function as a receptor for GALV and SSAV but not for FeLV-B. Substitution of human GLVR1 amino acids in the critical region of rat GLVR1 identified three amino acids as responsible for resistance to FeLV-B infection; two of these affect SSAV infection, but none affects GALV infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-1309898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-1335026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-1370096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-1381539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-1531369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-1652100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-1656443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-1691887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-1733113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-1850020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-1908564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-204584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-2078500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-2154701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-2454642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-2541919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-2683360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-3001650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-3009890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-4501200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-49058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-6083454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-6096719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-6304347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-8382297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-8411375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8411376-8445722
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:geneSymbol |
GLVR1,
Glvr-1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6737-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8411376-Amino Acid Sequence,
pubmed-meshheading:8411376-Animals,
pubmed-meshheading:8411376-DNA Mutational Analysis,
pubmed-meshheading:8411376-Humans,
pubmed-meshheading:8411376-Leukemia Virus, Feline,
pubmed-meshheading:8411376-Leukemia Virus, Gibbon Ape,
pubmed-meshheading:8411376-Mice,
pubmed-meshheading:8411376-Molecular Sequence Data,
pubmed-meshheading:8411376-Mutation,
pubmed-meshheading:8411376-Rats,
pubmed-meshheading:8411376-Receptors, Virus,
pubmed-meshheading:8411376-Recombinant Fusion Proteins,
pubmed-meshheading:8411376-Sarcoma Virus, Woolly Monkey,
pubmed-meshheading:8411376-Sequence Alignment,
pubmed-meshheading:8411376-Sequence Homology, Amino Acid,
pubmed-meshheading:8411376-Structure-Activity Relationship
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pubmed:year |
1993
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pubmed:articleTitle |
Mutation of amino acids within the gibbon ape leukemia virus (GALV) receptor differentially affects feline leukemia virus subgroup B, simian sarcoma-associated virus, and GALV infections.
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pubmed:affiliation |
Chester Beatty Laboratories, Institute of Cancer Research, London, England.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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