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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1993-11-24
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pubmed:abstractText |
Depletion of endogenous gamma interferon (IFN-gamma) with anti-IFN-gamma monoclonal antibody resulted in increased numbers of Brucella abortus in the spleen and liver of infected CBA mice. This increase was accompanied by a decrease in splenomegaly and a lower proportion of macrophages in the spleen. Furthermore, treatment of recipient mice with anti-IFN-gamma antibody blocked the adoptive transfer of resistance with immune T cells. Together, the results indicated that endogenous IFN-gamma plays an important role in mediating resistance to primary and secondary Brucella infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-1398950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-1612769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-1804781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-2509360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-3091058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-3100664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-3933006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-398327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-6195085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-6436036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-6814766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-81133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8406893-8418034
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4899-901
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8406893-Animals,
pubmed-meshheading:8406893-Antibodies, Monoclonal,
pubmed-meshheading:8406893-Brucella abortus,
pubmed-meshheading:8406893-Brucellosis,
pubmed-meshheading:8406893-Immunity, Innate,
pubmed-meshheading:8406893-Immunotherapy, Adoptive,
pubmed-meshheading:8406893-Interferon-gamma,
pubmed-meshheading:8406893-Mice,
pubmed-meshheading:8406893-Mice, Inbred CBA,
pubmed-meshheading:8406893-T-Lymphocytes
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pubmed:year |
1993
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pubmed:articleTitle |
Endogenous gamma interferon mediates resistance to Brucella abortus infection.
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pubmed:affiliation |
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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