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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-11-16
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pubmed:abstractText |
Intranasal inoculation of 12 young adult mice (strain TO) with Mycoplasma pulmonis protected all of them against vaginal colonization when they were challenged intravaginally 60 days later with the same mycoplasmal strain. In contrast, all 15 mice without a respiratory infection became colonized vaginally (geometric mean titre [GMT] 4.6 x 10(6) colour-changing units [c.c.u.]) when challenged in the same way. The GMT of serum antibody, measured by a microimmunofluorescence technique, prior to challenge was 200 and 8 for the oropharyngeally infected and unexposed mice, respectively. The GMT of antibody in vaginal washings from the two groups was 6 and 3, respectively. All four nude BALB/c mice were susceptible to vaginal colonization (GMT 5.6 x 10(6) c.c.u.) after oropharyngeal infection (GMT 5.1 x 10(4) c.c.u.) resulting from intranasal inoculation, as were all six nude mice (vaginal GMT 1.4 x 10(7) c.c.u.) that had not been inoculated intranasally. In contrast, all ten of their immunocompetent counterparts were resistant to vaginal colonization after oropharyngeal infection (GMT 1.3 x 10(3) c.c.u.), whereas all nine such mice that had not been infected oropharyngeally were susceptible to vaginal colonization (GMT 7.6 x 10(6) c.c.u.). These results show the important role that a respiratory infection has in protecting the vagina against colonization and that protection is dependent on a functioning T-lymphocyte system.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8405157-1193724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8405157-1278933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8405157-209470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8405157-2925238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8405157-3710524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8405157-3734429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8405157-4968002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8405157-5344119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8405157-6128472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8405157-6432856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8405157-6707467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8405157-8471540
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0950-2688
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
307-13
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:8405157-Animals,
pubmed-meshheading:8405157-Antibodies, Bacterial,
pubmed-meshheading:8405157-Disease Models, Animal,
pubmed-meshheading:8405157-Female,
pubmed-meshheading:8405157-Immunocompetence,
pubmed-meshheading:8405157-Mice,
pubmed-meshheading:8405157-Mice, Inbred BALB C,
pubmed-meshheading:8405157-Mice, Nude,
pubmed-meshheading:8405157-Mycoplasma,
pubmed-meshheading:8405157-Mycoplasma Infections,
pubmed-meshheading:8405157-Oropharynx,
pubmed-meshheading:8405157-Pharyngitis,
pubmed-meshheading:8405157-Specific Pathogen-Free Organisms,
pubmed-meshheading:8405157-Vaccination,
pubmed-meshheading:8405157-Vagina,
pubmed-meshheading:8405157-Vaginal Diseases
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pubmed:year |
1993
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pubmed:articleTitle |
Mycoplasma pulmonis infection of the murine oropharynx protects against subsequent vaginal colonization.
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pubmed:affiliation |
Division of Sexually Transmitted Diseases, Clinical Research Centre, Harrow, Middlesex.
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pubmed:publicationType |
Journal Article,
Comparative Study
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