| pubmed-article:8402894 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8402894 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:8402894 | lifeskim:mentions | umls-concept:C0205276 | lld:lifeskim |
| pubmed-article:8402894 | lifeskim:mentions | umls-concept:C0597600 | lld:lifeskim |
| pubmed-article:8402894 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:8402894 | lifeskim:mentions | umls-concept:C0599944 | lld:lifeskim |
| pubmed-article:8402894 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:8402894 | lifeskim:mentions | umls-concept:C0247849 | lld:lifeskim |
| pubmed-article:8402894 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8402894 | pubmed:dateCreated | 1993-11-18 | lld:pubmed |
| pubmed-article:8402894 | pubmed:abstractText | Bacteriophage T4 Alc protein participates in shutting off host transcription after infection of E. coli. It is demonstrated that Alc acts as a site-specific termination factor. The Alc sites occur frequently in E. coli DNA, resulting in early cessation of elongation in several tested transcription units. Alc-dependent termination requires unimpeded propagation of the elongating complex as it approaches the Alc site. Temporary halting of RNA polymerase within 10-15 bp before the Alc site prevents termination. Bacteriophage T4 transcription is protected from the action of Alc by overall substitution of cytosine with 5-hydroxymethyl cytosine in T4 DNA. In vitro methylation of CpG sequences in the vicinity of an Alc site abolishes the effect of Alc. Thus, Alc-dependent termination involves local sensing of the state of cytosine modification and a short-term "memory" of recent pausing. | lld:pubmed |
| pubmed-article:8402894 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8402894 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8402894 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8402894 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8402894 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8402894 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8402894 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:8402894 | pubmed:author | pubmed-author:WhiteTT | lld:pubmed |
| pubmed-article:8402894 | pubmed:author | pubmed-author:KutterEE | lld:pubmed |
| pubmed-article:8402894 | pubmed:author | pubmed-author:GoldfarbAA | lld:pubmed |
| pubmed-article:8402894 | pubmed:author | pubmed-author:KashlevMM | lld:pubmed |
| pubmed-article:8402894 | pubmed:author | pubmed-author:NudlerEE | lld:pubmed |
| pubmed-article:8402894 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8402894 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:8402894 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:8402894 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8402894 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8402894 | pubmed:pagination | 147-54 | lld:pubmed |
| pubmed-article:8402894 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8402894 | pubmed:meshHeading | pubmed-meshheading:8402894-... | lld:pubmed |
| pubmed-article:8402894 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8402894 | pubmed:articleTitle | Bacteriophage T4 Alc protein: a transcription termination factor sensing local modification of DNA. | lld:pubmed |
| pubmed-article:8402894 | pubmed:affiliation | Public Health Research Institute, New York, New York 10016. | lld:pubmed |
| pubmed-article:8402894 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8402894 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8402894 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8402894 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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