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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1977-4-15
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pubmed:abstractText |
The proximal tubular fluid albumin concentration of rats with immunologically induced nephrotic syndrome rose from 0.60 +/- 0.11 (SEM) mg/100 ml to 7.42 to 0.87 mg/100 ml. The glomerular filtration rate (GFR) was slightly depressed (P less than 0.001) and fractional water absorption unchanged (P greater than 0.45). Urinary albumin excretion rose from 0.18 +/- 0.03 (SEM) mg/100 g of body wt/24 hr to 78.5 +/- 39.5 mg/100 g/100 g of body wt/24 hr (P less than 0.001). The concentration of albumin in glomerular filtrate, calculated as the product of proximal tubular albumin concentration and fractional water absorption (4.53 +/- 0.60 mg [SEM]/100 ml), equalled that calculated from urine albumin concentration and whole kidney water absorption (4.14 +/- 0.84 mg/100 ml, P greater than 0.30). The data are interpreted to reflect a significant increase in filtered albumin and only a modest (if any) tubular albumin absorption in this study. Thus, the concept that tubular absorption plays a major role in the catabolism of albumin and the genesis of hypoalbuminemia in the nephrotic syndrome could not be confirmed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0085-2538
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9-17
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:839656-Absorption,
pubmed-meshheading:839656-Albumins,
pubmed-meshheading:839656-Albuminuria,
pubmed-meshheading:839656-Animals,
pubmed-meshheading:839656-Female,
pubmed-meshheading:839656-Glomerular Filtration Rate,
pubmed-meshheading:839656-Kidney Tubules, Proximal,
pubmed-meshheading:839656-Nephrons,
pubmed-meshheading:839656-Nephrotic Syndrome,
pubmed-meshheading:839656-Punctures,
pubmed-meshheading:839656-Rats
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pubmed:year |
1977
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pubmed:articleTitle |
Micropuncture studies of the filtration and absorption of albumin by nephrotic rats.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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