| pubmed-article:8395958 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8395958 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8395958 | lifeskim:mentions | umls-concept:C0373704 | lld:lifeskim |
| pubmed-article:8395958 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:8395958 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:8395958 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8395958 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:8395958 | lifeskim:mentions | umls-concept:C1524057 | lld:lifeskim |
| pubmed-article:8395958 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8395958 | pubmed:dateCreated | 1993-10-4 | lld:pubmed |
| pubmed-article:8395958 | pubmed:abstractText | The steroid pregnenolone (P) and its sulfate (PS) can accumulate in the central nervous system independent of peripheral sources. Pharmacologically, the sulphated form of P interacts with the GABAA receptor complex, and functional assays show that this steroid behaves as an allosteric GABAA receptor antagonist. The present study explored the effect of a single dose of P upon the sleep-EEG and concurrent secretion of growth hormone and cortisol in male volunteers. P increased the amount of time spent in slow wave sleep and depressed EEG sigma power. Sleep-associated nocturnal cortisol and growth hormone secretion remained unchanged, ruling out the possibility that P exerted its effect via altered regulation of these hormones. Furthermore, results from in vitro studies on the potency of P to activate gene transcription via corticosteroid receptors made a genomic action of P via hormone receptor-sensitive DNA sequences unlikely. We conclude that P acts in a non-genomic fashion at or in the vicinity of the benzodiazepine binding site, modulating allosterically the GABAA receptor like a partial inverse. | lld:pubmed |
| pubmed-article:8395958 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8395958 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8395958 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8395958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8395958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8395958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8395958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8395958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8395958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8395958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8395958 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8395958 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8395958 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:8395958 | pubmed:author | pubmed-author:SteigerAA | lld:pubmed |
| pubmed-article:8395958 | pubmed:author | pubmed-author:HolsboerFF | lld:pubmed |
| pubmed-article:8395958 | pubmed:author | pubmed-author:RupprechtRR | lld:pubmed |
| pubmed-article:8395958 | pubmed:author | pubmed-author:RotheBB | lld:pubmed |
| pubmed-article:8395958 | pubmed:author | pubmed-author:GuldnerJJ | lld:pubmed |
| pubmed-article:8395958 | pubmed:author | pubmed-author:HemmeterUU | lld:pubmed |
| pubmed-article:8395958 | pubmed:author | pubmed-author:VedderHH | lld:pubmed |
| pubmed-article:8395958 | pubmed:author | pubmed-author:TrachselLL | lld:pubmed |
| pubmed-article:8395958 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8395958 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:8395958 | pubmed:volume | 615 | lld:pubmed |
| pubmed-article:8395958 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8395958 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8395958 | pubmed:pagination | 267-74 | lld:pubmed |
| pubmed-article:8395958 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8395958 | pubmed:meshHeading | pubmed-meshheading:8395958-... | lld:pubmed |
| pubmed-article:8395958 | pubmed:meshHeading | pubmed-meshheading:8395958-... | lld:pubmed |
| pubmed-article:8395958 | pubmed:meshHeading | pubmed-meshheading:8395958-... | lld:pubmed |
| pubmed-article:8395958 | pubmed:meshHeading | pubmed-meshheading:8395958-... | lld:pubmed |
| pubmed-article:8395958 | pubmed:meshHeading | pubmed-meshheading:8395958-... | lld:pubmed |
| pubmed-article:8395958 | pubmed:meshHeading | pubmed-meshheading:8395958-... | lld:pubmed |
| pubmed-article:8395958 | pubmed:meshHeading | pubmed-meshheading:8395958-... | lld:pubmed |
| pubmed-article:8395958 | pubmed:meshHeading | pubmed-meshheading:8395958-... | lld:pubmed |
| pubmed-article:8395958 | pubmed:meshHeading | pubmed-meshheading:8395958-... | lld:pubmed |
| pubmed-article:8395958 | pubmed:meshHeading | pubmed-meshheading:8395958-... | lld:pubmed |
| pubmed-article:8395958 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8395958 | pubmed:articleTitle | Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation. | lld:pubmed |
| pubmed-article:8395958 | pubmed:affiliation | Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany. | lld:pubmed |
| pubmed-article:8395958 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8395958 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8395958 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8395958 | lld:pubmed |
