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pubmed-article:8395247pubmed:abstractTextStructure and activity relationships of (methoxyalkyl)thiazole and 4-methoxytetrahydropyran series of 5-lipoxygenase inhibitors are reviewed. One member of the 4-methoxytetrahydropyran series, 6-([fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl)phenoxy]methyl) -1- methylquinol-2-one (ICI D2138), is undergoing clinical evaluation.lld:pubmed
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pubmed-article:8395247pubmed:articleTitleStructure and activity relationships leading to the discovery of ICI D2138, a selective, potent and orally active inhibitor of 5-lipoxygenase.lld:pubmed
pubmed-article:8395247pubmed:affiliationResearch Department 1, ICI Pharmaceuticals, Alderley Park, Macclesfield, UK.lld:pubmed
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