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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
1993-8-10
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pubmed:abstractText |
The presence of synaptic proteins involved in excitation/secretion coupling was examined in ten small cell lung cancer lines. N-Type calcium channels (omega-conotoxin receptors), synaptotagmin (p65) and syntaxin (HPC-1) were detected in eight. Co-immunoprecipitation experiments indicated that syntaxin can form a complex with synaptotagmin and calcium channels. The expression of synaptotagmin in small cell lung cancer may elicit an autoimmune response that reduces transmitter release at the nerve terminal.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-((3-cholamidopropyl)dimethylammoni...,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/STX1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Stx1a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Synaptotagmin I,
http://linkedlifedata.com/resource/pubmed/chemical/Synaptotagmins,
http://linkedlifedata.com/resource/pubmed/chemical/Syntaxin 1,
http://linkedlifedata.com/resource/pubmed/chemical/omega-Conotoxin GVIA
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
326
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8391990-Animals,
pubmed-meshheading:8391990-Antibodies, Monoclonal,
pubmed-meshheading:8391990-Antigens, Surface,
pubmed-meshheading:8391990-Blotting, Western,
pubmed-meshheading:8391990-Calcium Channels,
pubmed-meshheading:8391990-Calcium-Binding Proteins,
pubmed-meshheading:8391990-Carcinoma, Small Cell,
pubmed-meshheading:8391990-Cholic Acids,
pubmed-meshheading:8391990-Humans,
pubmed-meshheading:8391990-Immunosorbent Techniques,
pubmed-meshheading:8391990-Lung Neoplasms,
pubmed-meshheading:8391990-Membrane Glycoproteins,
pubmed-meshheading:8391990-Nerve Tissue Proteins,
pubmed-meshheading:8391990-Peptides,
pubmed-meshheading:8391990-Rats,
pubmed-meshheading:8391990-Synaptotagmin I,
pubmed-meshheading:8391990-Synaptotagmins,
pubmed-meshheading:8391990-Syntaxin 1,
pubmed-meshheading:8391990-Tumor Cells, Cultured,
pubmed-meshheading:8391990-omega-Conotoxin GVIA
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pubmed:year |
1993
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pubmed:articleTitle |
Expression of synaptotagmin and syntaxin associated with N-type calcium channels in small cell lung cancer.
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pubmed:affiliation |
INSERM U374, Faculté de Medecine Secteur Nord, Marseille, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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