Linked Life Data

8391523

Source:http://linkedlifedata.com/resource/pubmed/id/8391523

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1993-8-5
pubmed:abstractText
Eight of 19 calves born to bovine viral diarrhea virus (BVDV)-negative and -immunocompetent dams were determined to be infected with a noncytopathic strain of BVDV. Six of the 8 calves had diarrhea and 2 had no clinical signs of disease. In 3 euthanatized calves, lesions consistent with mucosal disease were found throughout the gastrointestinal tract, and the virus was isolated from the spleen, lymph nodes, and small intestine. In 5 calves, BVDV was isolated from mononuclear cells in blood samples obtained 21 days apart, indicating persistent infection. The virus was not isolated from sera obtained from 2 calves, with chronic nonclinical infections, that had neutralizing antibody titers > or = 1:512 against bovine viral diarrhea-Singer virus and titers > or = 1:256 against the persistent BVDV. Twenty-one days after vaccination with a vaccine that contained inactivated noncytopathic and cytopathic biotypes of BVDV, 4 of 5 persistently infected calves had neutralizing antibody titers < or = 1:4 against the bovine viral diarrhea-Singer virus and their persistent virus. Prior to vaccination, 2 of 11 virus-negative calves had neutralizing antibody titers < or = 1:128 against the bovine viral diarrhea-Singer virus, and after vaccination, only 1 virus-negative calf had a titer < or = 1:512. At 149 days after revaccination and prior to weaning, 4 virus-negative calves had neutralizing antibody titers < or = 1:512 (range, 1:16 to 1:384). Under the specific conditions in this herd, we were not able to detect a beneficial effect of vaccination.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0003-1488
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
202
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1849-54
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Investigation of an epizootic of bovine viral diarrhea virus infection in calves.
pubmed:affiliation
Department of Large Animal Clinical Sciences, Veterinary Medical Center, College of Veterinary Medicine, Michigan State University, East Lansing 48824.
pubmed:publicationType
Journal Article