rdf:type |
|
lifeskim:mentions |
umls-concept:C0020855,
umls-concept:C0022144,
umls-concept:C0301625,
umls-concept:C0591833,
umls-concept:C0598934,
umls-concept:C1510438,
umls-concept:C1514873,
umls-concept:C1515655,
umls-concept:C1519692,
umls-concept:C1521991,
umls-concept:C1524003,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636
|
pubmed:issue |
2
|
pubmed:dateCreated |
1977-4-15
|
pubmed:abstractText |
A radioimmunoassay was used to quantitate the number of tumor cell-bound IgG1 anti-tumor antibody molecules required to cause suppression of tumor growth in C3H mice. Radiolabeled anti-IgG1 was used to detect cell-bound IgG1 antibody. The assay was calibrated by using TNP-coupled tumor cells that had a known number of bound IgG1 anti DNP molecules. Between 70,000 and 130,000 IgG1 anti-tumor antibody molecules per tumor cell were sufficient to cause 50% suppression of tumor growth in mice inoculated with appriximately 50,000 tumor cells.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0022-1767
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
118
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
498-504
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:839068-Animals,
pubmed-meshheading:839068-Antibodies, Neoplasm,
pubmed-meshheading:839068-Antibody Specificity,
pubmed-meshheading:839068-Binding Sites, Antibody,
pubmed-meshheading:839068-Cell Transformation, Neoplastic,
pubmed-meshheading:839068-Female,
pubmed-meshheading:839068-Immunoglobulin G,
pubmed-meshheading:839068-Immunosuppressive Agents,
pubmed-meshheading:839068-Isoantibodies,
pubmed-meshheading:839068-Lymphoma,
pubmed-meshheading:839068-Mice,
pubmed-meshheading:839068-Mice, Inbred BALB C,
pubmed-meshheading:839068-Plasmacytoma,
pubmed-meshheading:839068-Rabbits,
pubmed-meshheading:839068-Radioimmunoassay
|
pubmed:year |
1977
|
pubmed:articleTitle |
Antibody-mediated suppression of tumor growth. III. Molecular assay of murine IgG1 alloantibody required to cause tumor suppression in vivo.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|