Linked Life Data

8388813

Source:http://linkedlifedata.com/resource/pubmed/id/8388813

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-6-30
pubmed:abstractText
Previously, we showed that sodium perchlorate treatment of larval frogs (Xenopus laevis) interferes with the normal expansion of T and B lymphocytes and development of an adult-type T-cell population. It was unclear whether these effects resulted from preventing metamorphosis or from long-term thyroid hormone (TH) deprivation. To try to distinguish between these possibilities, we have now studied the effects of perchlorate treatment beginning immediately after metamorphosis. After 5 months, treated animals, but not untreated controls, had large thyroid goiters, were significantly smaller, and had significantly fewer erythrocytes, thymocytes, and splenocytes. Although the number of IgM- splenocytes and thymocytes was reduced, the estimated percent of major histocompatibility complex (MHC) class II+ cells within this subset was not significantly different from that of controls. Furthermore, splenocytes from perchlorate-treated frogs could respond normally by [3H]TdR incorporation to the T-cell mitogens, phytohemagglutinin-P (PHA) and concanavalin A (Con A). Thus, unlike perchlorate-treated larvae, perchlorate-treated juveniles appear to be able to develop T cells with an adult phenotype competent to respond to activation and proliferation signals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0145-305X
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-64
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Effects of thyroid hormone deprivation on immunity in postmetamorphic frogs.
pubmed:affiliation
Department of Microbiology & Immunology and Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.