Linked Life Data

8384165

Source:http://linkedlifedata.com/resource/pubmed/id/8384165

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-4-22
pubmed:abstractText
The existence and quantitative contribution of an adaptive increase in whole-body metabolic efficiency in response to low caloric intake was examined after prolonged underfeeding in the rat. 24h energy expenditures (EE) and body composition were measured in chronically underfed rats which had been maintaining a stable body weight for several months after an initial period of substantial weight loss. Comparisons were made with ad libitum fed controls. The mean coefficient of variation for daily EE, assessed over three consecutive days, was 3% (range 1.7-4.0%) in the control group and 1.6% (range 0.7-2.1%) in the chronically underfed group, and hence reflect steady state conditions. Body composition was determined by chemical analysis, and as a proportion of body weight (BW), the fat content in the underfed group was reduced by 40% whereas lean body mass was significantly higher by 8%. Independently of the criteria utilized for metabolically active mass, 24h EE was lower in the underfed group than in controls, by 17%, 14% and 8% as a function of BW0.66, BW0.75 and lean body mass respectively (P < 0.01). Underfeeding was also associated with a substantial reduction in the level of external work, but in ad libitum fed animals similar reductions in external work (induced by limiting locomotion) failed to alter 24h EE significantly. Taken together, these studies provide evidence for an increased metabolic efficiency in response to low calorie intake well beyond the period of dynamic weight loss.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0307-0565
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
115-23
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
24 hour energy expenditure several months after weight loss in the underfed rat: evidence for a chronic increase in whole-body metabolic efficiency.
pubmed:affiliation
Department of Physiology, University of Geneva, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't