Linked Life Data

8384075

Source:http://linkedlifedata.com/resource/pubmed/id/8384075

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-4-20
pubmed:abstractText
A detailed analysis was made of the karyotype of human hepatocarcinoma cell line PLC-PRF-5 containing an integrated hepatitis B viral genome and 10 mutant clones derived from the line. These clones are drug resistant and display features of cell differentiation. Cytogenetic manifestations of gene amplification common to many cells resistant to drugs were not observed in these clones, but certain tendencies of karyotype evolution involving material from chromosomes 7 and 11, as well as chromosomes 5 and 15, were recorded for a group of cytostatic-resistant clones. An increase in polyploid cell number and number of cells with chromosome pulverization as compared with the original line was noted in the clones. This phenomenon may be related to the cytopathic effect of the hepatitis B viral proteins, which have a higher expression in the clones.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0165-4608
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-51
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Cytogenetic analysis of human hepatocarcinoma cell line PLC-PRF-5 and its mutant clones with different degrees of cell differentiation.
pubmed:affiliation
D.I. Ivanovsky Institute of Virology of Russian Academy of Medical Sciences, Moscow.
pubmed:publicationType
Journal Article