Linked Life Data

8384022

Source:http://linkedlifedata.com/resource/pubmed/id/8384022

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-4-22
pubmed:abstractText
Nerve growth factor and its receptor(s) are present in several parts of the hippocampus (CA1, CA3, dentate gyrus) but nothing is known about their function in this area which plays a fundamental role in learning and memory processes. NGF delivered exogenously to hippocampal slices causes a concentration-dependent, marked reduction in the expression (but not the induction) of long term potentiation (LTP) without altering basal synaptic transmission. The effect is already half maximal at 0.05-0.1 ng ml-1 NGF, is reversible after removal of this growth factor, and is also detectable with a modified version of NGF which has lost its neurite outgrowth promoting activity in PC12 cells. These findings point to a role for hippocampal NGF as a possible modulator of learning and memory processes. Such modulation would be mediated by high-affinity receptors functionally distinct from those promoting morphological differentiation of PC12 cells and other NGF target cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Nerve growth factor inhibits the expression of long-term potentiation in hippocampal slices.
pubmed:affiliation
Department of Experimental Medicine and Biochemistry, II University of Rome, Tor Vergata, Italy.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't