Linked Life Data

8383572

Source:http://linkedlifedata.com/resource/pubmed/id/8383572

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-4-12
pubmed:abstractText
Groups of 6 rats were treated for 5 days with either reserpine hydrochloride (5 mg/kg i.p., per diem), or saline. Regional binding of the histamine H3 agonist N alpha-[3H]methyl-histamine ([3H]NAMH) was determined in forebrain sections by quantitative autoradiography and Scatchard analysis. Highest maximal binding was in nucleus accumbens (107 +/- 18 fmol/mg) and corpus striatum (58 +/- 9 fmol/mg), where the apparent affinity was close to 4 nM. Maximal binding of [3H]NAMH in the insular cortex (39 +/- 6 fmol/mg) was higher than in other cortical areas examined. Reserpine treatment produced a 50% decrease in both the Bmax and the apparent Kd in the corpus striatum and nucleus accumbens, but binding parameters in the cortex and septum were unaltered. Therefore, the response of H3 receptors in rat forebrain to reserpine treatment for 5 days was regionally heterogenous such that maximal [3H]NAMH binding was typically higher in insular cortex (36 +/- 6 fmol/mg) than in corpus striatum (24 +/- 3 fmol/mg) of reserpine-treated rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
602
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Altered histamine H3 binding in rat forebrain after reserpine treatment.
pubmed:affiliation
Montreal Neurological Institute, McGill University, Que., Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't