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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1993-3-30
|
| pubmed:abstractText |
The prevalence of hepatitis A, B, C, and D viruses was studied in 467 military personnel with human immunodeficiency virus type 1 (HIV-1) infection. Antibody to hepatitis C virus (anti-HCV) by first-generation ELISA was found in 136 (29%). Of sera repeatedly reactive for anti-HCV by first-generation ELISA, two-antigen recombinant immunoblot assay (RIBA) was positive in 41 (32%) and four-antigen RIBA was positive in 55 (41%). Four-antigen RIBA was positive in 33 (30%) of the 109 with an OD on ELISA of < or = 2.0 compared with 22 (81%) of the 27 with an OD > 2.0 (P < .001). Anti-HCV detected by four-antigen RIBA was associated with increasing age, black or Hispanic race, and antibody to hepatitis B core antigen. When patients with hepatitis B surface antigen were excluded, elevated alanine aminotransferase was found in 5 (8%) of 63 with a negative RIBA and 13 (28%) of 47 with a positive RIBA (P = .006). While RIBA was negative in more than half of those with anti-HCV by ELISA, 55 (12%) of these HIV-1 infected personnel had anti-HCV detected by RIBA, which was associated with a strong reaction by ELISA, elevated liver enzymes, coinfection with hepatitis B, minority race, and older age.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
167
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
715-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8382719-AIDS-Related Opportunistic Infections,
pubmed-meshheading:8382719-Alanine Transaminase,
pubmed-meshheading:8382719-Analysis of Variance,
pubmed-meshheading:8382719-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:8382719-Female,
pubmed-meshheading:8382719-HIV-1,
pubmed-meshheading:8382719-Hepacivirus,
pubmed-meshheading:8382719-Hepatitis, Viral, Human,
pubmed-meshheading:8382719-Hepatitis Antibodies,
pubmed-meshheading:8382719-Hepatitis B Surface Antigens,
pubmed-meshheading:8382719-Hepatitis C,
pubmed-meshheading:8382719-Humans,
pubmed-meshheading:8382719-Immunoblotting,
pubmed-meshheading:8382719-Male,
pubmed-meshheading:8382719-Military Personnel,
pubmed-meshheading:8382719-Naval Medicine,
pubmed-meshheading:8382719-Regression Analysis,
pubmed-meshheading:8382719-Sex Factors,
pubmed-meshheading:8382719-Syphilis,
pubmed-meshheading:8382719-United States
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Recombinant immunoblot assays for hepatitis C in human immunodeficiency virus type 1-infected US Navy personnel.
|
| pubmed:affiliation |
Dept. of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
|