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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-3-17
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pubmed:abstractText |
Urate strongly inhibited DNA damage induced by adriamycin (AD)-Fe3+ in the presence of H2O2. Deoxyribose (DOR) was degraded during the interaction of Ad-Fe3+ with H2O2, and urate strongly inhibited the DOR degradation. However, hydroxyl radical (HO.) scavengers did not always prevent the DOR degradation. ESR signal of 5,5-dimethyl-1-pyroline N-oxide-hydroxyl radical adduct was detected during the interaction of Ad-Fe3+ with H2O2. Mannitol and DNA strongly diminished the ESR signal but urate only poorly did. These results suggested that inhibitory effect of urate on the H2O2-dependent AD-Fe(3+)-induced DNA damage was not always due to trap only HO.. Lipid peroxidation of erythrocyte membrane was induced by AD-Fe3+ alone and H2O2 slightly inhibited the peroxidation reaction. Urate could not inhibit the Ad-Fe(3+)-induced lipid peroxidation. These results indicate that oxygen radical species which causes the lipid peroxidation does not involve in the H2O2-dependent Ad-Fe(3+)-induced DNA damage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0034-5164
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
75-85
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8381978-Antioxidants,
pubmed-meshheading:8381978-DNA Damage,
pubmed-meshheading:8381978-Deoxyribose,
pubmed-meshheading:8381978-Doxorubicin,
pubmed-meshheading:8381978-Electron Spin Resonance Spectroscopy,
pubmed-meshheading:8381978-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:8381978-Erythrocyte Membrane,
pubmed-meshheading:8381978-Humans,
pubmed-meshheading:8381978-Hydrogen Peroxide,
pubmed-meshheading:8381978-Lipid Peroxidation,
pubmed-meshheading:8381978-Mannitol,
pubmed-meshheading:8381978-Organometallic Compounds,
pubmed-meshheading:8381978-Oxidation-Reduction,
pubmed-meshheading:8381978-Plasmids,
pubmed-meshheading:8381978-Protein Kinase C,
pubmed-meshheading:8381978-Uric Acid
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pubmed:year |
1993
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pubmed:articleTitle |
Inhibitory effect of urate on oxidative damage induced by adriamycin-Fe3+ in the presence of H2O2.
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pubmed:affiliation |
Department of Biochemistry, Hokkaido Institute of Pharmaceutical Sciences, Otaru, Japan.
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pubmed:publicationType |
Journal Article
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