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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1993-3-17
|
| pubmed:abstractText |
Hypochlorous acid (HOCI) is a powerful oxidizing and chlorinating agent produced by the neutrophil enzyme myeloperoxidase. The antioxidant defenses of freshly prepared human plasma against HOCI/OCI- were explored. Addition of HOCI/OCI- to plasma caused rapid oxidation of ascorbic acid and thiol (-SH) groups but not of uric acid. Plasma -SH groups (which are known to be largely located on albumin) were quantitatively the most important scavenger of HOCI/OCI-, but adding extra ascorbate to plasma caused this molecule to have a more important scavenging role against HOCI/OCI-. Added HOCI/OCI- produced no detectable lipid peroxidation in plasma or depletion of lipid-soluble antioxidants (alpha-tocopherol or ubiquinol-10). No evidence of oxidative damage to protein amino acid residues (other than -SH) was detected by the carbonyl assay. It seems that -SH groups are a major target of attack by HOCI/OCI- in vivo, and plasma albumin may be an important protective antioxidant. Ascorbic acid might also play a protective role, especially in individuals supplemented with this vitamin. Ascorbate might also be important in extracellular fluids with low albumin concentrations such as synovial, respiratory tract lining, and cerebrospinal fluids.
|
| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-2143
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
121
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
257-62
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1993
|
| pubmed:articleTitle |
Antioxidant protection against hypochlorous acid in human plasma.
|
| pubmed:affiliation |
Department of Pulmonary-Critical Care Medicine, University of California-Davis Medical Center, Sacramento 95817.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|