Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1993-3-11
|
| pubmed:abstractText |
We present four patients with adult T-cell leukemia (ATL) derived from a novel T-cell subset (CD4-, CD8- [double-negative, DN], T-cell receptor [TCR] alpha beta+). In the ATL cells of these patients, neither gene nor surface expression of CD4 and CD8 antigens was detected. Clinical and laboratory data showed no difference between DN-ATL and CD4+ATL patients. In contrast to typical CD4+ATL cells, DN-ATL cells were shown to express the protein and messenger RNA (mRNA) for S100 beta in immunocytochemical assay and the reverse-transcription polymerase chain reaction assay. The mean fluorescence intensity of the TCR/CD3 complex was extremely low in all four DN-ATL patients as well as in typical CD4+ ATL. All four patients had TCR beta and gamma chain gene rearrangements, with deletion of TCR delta chain gene and mRNA expression for TCR alpha, beta, and CD3 delta but not for TCR gamma and delta chain genes. Thus, CD4- CD8- TCR alpha beta T cells are also a target for human T-cell lymphotrophic virus type I-induced leukemogenesis. In addition, expression of the TCR alpha beta/CD3 complex on the DN-ATL cells was further diminished by the addition of anti-CD3 or anti-TCR alpha beta monoclonal antibody. These results suggest that the decreased expression of the TCR alpha beta/CD3 complex by ATL cells plays a key role in the development of ATL, irrespective of CD4 expression.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/S100 Proteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
81
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1032-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8381310-Adult,
pubmed-meshheading:8381310-Aged,
pubmed-meshheading:8381310-Aged, 80 and over,
pubmed-meshheading:8381310-Antibodies, Monoclonal,
pubmed-meshheading:8381310-Antigens, CD3,
pubmed-meshheading:8381310-Antigens, CD4,
pubmed-meshheading:8381310-Antigens, CD8,
pubmed-meshheading:8381310-Base Sequence,
pubmed-meshheading:8381310-Gene Deletion,
pubmed-meshheading:8381310-Gene Expression,
pubmed-meshheading:8381310-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:8381310-Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor,
pubmed-meshheading:8381310-Humans,
pubmed-meshheading:8381310-Immunophenotyping,
pubmed-meshheading:8381310-Leukemia, T-Cell,
pubmed-meshheading:8381310-Male,
pubmed-meshheading:8381310-Middle Aged,
pubmed-meshheading:8381310-Molecular Sequence Data,
pubmed-meshheading:8381310-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8381310-S100 Proteins
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Double-negative (CD4- CD8-) T cells from adult T-cell leukemia patients also have poor expression of the T-cell receptor alpha beta/CD3 complex.
|
| pubmed:affiliation |
Second Department of Internal Medicine, Kumamoto University Medical School, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|