Linked Life Data

8372802

Source:http://linkedlifedata.com/resource/pubmed/id/8372802

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1993-10-8
pubmed:abstractText
In response to vascular injury, such as occurs in acute or chronic atherosclerosis, vascular smooth muscle cells (VSMCs) proliferate and migrate, ultimately contributing to vessel narrowing. Several growth agonists, including platelet-derived growth factor and fibroblast growth factor, are known to cause VSMCs to proliferate and are believed to be present at sites of vessel injury. Targets for inhibiting VSMC growth or migration in the presence of multiple growth agonists include genes that are induced in common by VSMC growth factors. This article summarizes the in vivo and in vitro findings of experiments designed to investigate the regulation of tissue factor in VSMCs in 2 animal models. The findings demonstrate that tissue factor is rapidly induced by growth factors in VSMC culture and by balloon injury in aortic media, and they suggest that VSMCs may play a major role in mediating the early thrombotic response. Strategies designed to inhibit the response of VSMCs to growth agonists may therefore have important implications for the treatment of intravascular thrombosis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-9149
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
55C-60C
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Tissue factor regulation in vascular smooth muscle: a summary of studies performed using in vivo and in vitro models.
pubmed:affiliation
Department of Medicine, Mt. Sinai School of Medicine, New York, New York 10029.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Review