Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1993-10-14
|
| pubmed:abstractText |
To determine the interstrain genomic diversity and molecular phylogeny of the recently identified variants of human T-cell lymphotropic virus type I (HTLV-I) in Melanesia, we enzymatically amplified, then directly sequenced representative regions of the gag, pol, and env genes of HTLV-I strains from 10 members of four families, including one family from Papua New Guinea and three families from the Solomon Islands. When aligned and compared to a Japanese strain of HTLV-I (ATK), the Melanesian HTLV-I strains differed by 7.6 to 8.7% in the gag, 7.1 to 9.3% in the pol, and 7.3 to 8.2% in the env gene regions. Based on 931 nucleotides, the overall sequence divergence of the 10 Melanesian HTLV-I strains from HTLV-I ATK was 7.3 to 8.1% (68 to 75 base substitutions). The intrafamilial genetic heterogeneity among these virus strains was nil to 0.2%, while the interfamilial sequence variation between HTLV-I strains from the Solomon Islands and those from Papua New Guinea was 3.4 to 4.2%, and the genetic heterogeneity among virus strains from the three Solomon Islands families was 0.2 to 0.9%. Using the maximum parsimony and neighbor-joining methods, phylogenetic analysis indicated that the HTLV-I strains from Papua New Guinea and the Solomon Islands formed a monophyletic group and that the Melanesian and cosmopolitan strains of HTLV-I have evolved along two major geographically dependent lineages.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0042-6822
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
196
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
506-13
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:8372432-Base Sequence,
pubmed-meshheading:8372432-Family,
pubmed-meshheading:8372432-Female,
pubmed-meshheading:8372432-Genes, Viral,
pubmed-meshheading:8372432-Genes, env,
pubmed-meshheading:8372432-Genes, gag,
pubmed-meshheading:8372432-Genes, pol,
pubmed-meshheading:8372432-Genetic Variation,
pubmed-meshheading:8372432-Genome, Viral,
pubmed-meshheading:8372432-HTLV-I Infections,
pubmed-meshheading:8372432-Human T-lymphotropic virus 1,
pubmed-meshheading:8372432-Humans,
pubmed-meshheading:8372432-Male,
pubmed-meshheading:8372432-Melanesia,
pubmed-meshheading:8372432-Molecular Sequence Data,
pubmed-meshheading:8372432-Papua New Guinea,
pubmed-meshheading:8372432-Phylogeny,
pubmed-meshheading:8372432-Polymerase Chain Reaction,
pubmed-meshheading:8372432-Sequence Analysis, DNA,
pubmed-meshheading:8372432-Sequence Homology, Amino Acid,
pubmed-meshheading:8372432-Sequence Homology, Nucleic Acid
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Interfamilial and intrafamilial genomic diversity and molecular phylogeny of human T-cell lymphotropic virus type I from Papua New Guinea and the Solomon Islands.
|
| pubmed:affiliation |
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
|
| pubmed:publicationType |
Journal Article
|