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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5127
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pubmed:dateCreated |
1993-10-4
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pubmed:abstractText |
Expression of either the CD4 or CD8 glycoproteins discriminates two functionally distinct lineages of T lymphocytes. A null mutation in the gene encoding CD4 impairs the development of the helper cell lineage that is normally defined by CD4 expression. Infection of CD4-null mice with Leishmania has revealed a population of functional helper T cells that develops despite the absence of CD4. These CD8- alpha beta T cell receptor+ T cells are major histocompatibility complex class II-restricted and produce interferon-gamma when challenged with parasite antigens. These results indicate that T lymphocyte lineage commitment and peripheral function need not depend on the function of CD4.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
261
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1448-51
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8367726-Animals,
pubmed-meshheading:8367726-Antigens, CD4,
pubmed-meshheading:8367726-Antigens, CD8,
pubmed-meshheading:8367726-Antigens, Protozoan,
pubmed-meshheading:8367726-B-Lymphocytes,
pubmed-meshheading:8367726-Base Sequence,
pubmed-meshheading:8367726-CD4-CD8 Ratio,
pubmed-meshheading:8367726-Histocompatibility Antigens Class II,
pubmed-meshheading:8367726-Hypersensitivity, Delayed,
pubmed-meshheading:8367726-Interferon-gamma,
pubmed-meshheading:8367726-Leishmania tropica,
pubmed-meshheading:8367726-Leishmaniasis, Cutaneous,
pubmed-meshheading:8367726-Mice,
pubmed-meshheading:8367726-Mice, Inbred C57BL,
pubmed-meshheading:8367726-Molecular Sequence Data,
pubmed-meshheading:8367726-Mutation,
pubmed-meshheading:8367726-Oligodeoxyribonucleotides,
pubmed-meshheading:8367726-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8367726-T-Lymphocytes,
pubmed-meshheading:8367726-T-Lymphocytes, Helper-Inducer
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pubmed:year |
1993
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pubmed:articleTitle |
Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice.
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pubmed:affiliation |
Department of Medicine, University of California, San Francisco 94143-0654.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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